A sequence pattern common to T cell epitopes.

Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria

Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development...

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes

Burkholderia pseudomallei (Bp) is an environmental bacterial pathogen that causes potentially lethal sepsis in susceptible individuals and is considered a Category B, Tier-1 biothreat agent. As such, it is crucial to gain an improved understanding of protective immunity and potential vaccine candidates. The nature of immune correlates dictating why most exposed individuals in endemic regions un...

Novel HLA-Cw8-Restricted T Cell Epitopes

Immunoprotective Zeishmania major Synthetic T Cell Epitopes

Using the predictive algorithm of Rothbard and Taylor (1988 . EMBOJ. 7:93) and the primary structure of gp63 (Button, L., and M.R . McMaster. 1988 . J. Exp. Med. 167:724 ; Miller, R.A., S.G . Reed, and M. Parsons . 1990 . Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4' cells . One of the...

Cross-conservation of T-cell epitopes

A novel avian-origin H7N9 influenza strain emerged in China in April 2013. Since its re-emergence in October-November 2013, the number of reported cases has accelerated; more than 220 laboratory-confirmed cases and 112 deaths (case fatality rate of 20-30%) have been reported. The resurgence of H7N9 has re-emphasized the importance of making faster and more effective influenza vaccines than thos...